* - corresponding author; # - equally contributed authors; bold - group members


Molecular characterization of the circadian clock in paediatric leukaemia patients: a prospective study protocol. Ludwig M, Basti A, Yalçin M, Schulte JH, Relógio A*. BMC Pediatr. 2023.  PMID: 36870963

Chronotherapy in Glioblastoma: state of the art and future perspectives. Petković M, Henis M, Heese O, Relógio A*. EBioMedicine. 2023. PMID: 36796229


Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock. Fuhr L, Basti A, Brás TS, Duarte MF, Relógio A*. Int J Mol Sci. 2022. PMID: 36012399

Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells. Basti A, Malhan D, Dumbani M, Dahlmann M, Stein U, Relógio A*. Cancers (Basel). 2022. PMID: 35884519

Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes. Malhan D, Basti A, Relógio A*. NPJ Syst Biol Appl. 2022PMID: 35552415

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health. Yalçin M, Mundorf A, Thiel F, Amatriain-Fernández S, Kalthoff IS, Beucke JC, Budde H, Garthus-Niegel S, Peterburs J, Relógio A. Front Physiol. 2022. PMID: 35547585

Analysis of more than 20,000 injuries in European professional football by using a citizen science-based approach: An opportunity for epidemiological research? Hoenig T, Edouard P, Krause M, Malhan D, Relógio A, Junge A, Hollander K. J Sci Med Sport. 2022. PMID: 34916169

— 2021 —

A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes.Yalçin M, Malhan D, Basti A, Peralta AR, Ferreira JJ, Relógio A*. Cancers (Basel).2021 PMID: 34885088

A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer. Hesse J#, Martinelli J#, Aboumanify O#, Ballesta A*, Relógio A*. CSBJ. 2021 PMID: 34630937

Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day. Basti A#, Yalçin M#, Herms D#, Hesse J, Aboumanify O, Li Y, Aretz Z, Garmshausen J, El-Athman R, Hastermann M, Blottner D, Relógio A*. BMJ Open Sport Exerc Med. 2021 PMID: 33680499

Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea. Gaspar LS, Hesse J, Yalçin M, Santos B, Carvalhas-Almeida C, Ferreira M, Moita J, Relógio A, Cavadas C, Álvaro AR. EBioMedicine. 2021  PMID: 33647771

— 2020 —

An Optimal Time for Treatment-Predicting Circadian Time by Machine Learning and Mathematical Modelling. Hesse J, Malhan D, Yalҫin M, Aboumanify O, Basti A, Relógio A*. Cancers (Basel). 2020  PMID: 33114254

Circadian Dysregulation of the TGFβ/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells. Li Y, Basti A, Yalçin M, Relógio A*. iScience. 2020  PMID: 33083720

The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP/PS1 Mouse Model of Alzheimer’s Disease. Furtado A, Astaburuaga R, Costa A, Duarte AC, Gonçalves I, Cipolla-Neto J, Lemos MC, Carro E, Relógio A, Santos CRA, Quintela T. J Alzheimers Dis. 2020  PMID: 32741824

Effect of naive and cancer-educated fibroblasts on colon cancer cell circadian growth rhythm. Parascandolo A, Bonavita R, Astaburuaga R, Sciuto A, Reggio S, Barra E, Corcione F, Salvatore M, Mazzoccoli G, Relógio A, Laukkanen MO. Cell Death Dis. 2020  PMID: 32341349

Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease. Yalçin M, El-Athman R, Ouk K, Priller J, Relógio A*. Cancers (Basel). 2020  PMID: 32295075

The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in A Zebrafish Xenograft Colon Cancer Model. Basti A, Fior R, Yalҫin M, Póvoa V, Astaburuaga R, Li Y, Naderi J, Godinho Ferreira M*, Relógio A*. Cancers (Basel). 2020 PMID: 32244760

The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction. Mazzoccoli G*, Vinciguerra M, Carbone A, Relógio A*. Pathogens. 2020 PMID: 32012758

— 2019 —

A Mathematical Model of Lysosomal Ion Homeostasis Points to Differential Effects of Cl Transport in Ca2+ Dynamics. Astaburuaga R, Quintanar Haro OD, Stauber T, Relógio A*. Cells. 2019 PMID: 31623161

A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics. Genov N, Castellana S, Scholkmann F, Capocefalo D, Truglio M, Rosati J, Turco EM, Biagini T, Carbone A, Mazza T, Relógio A*, Mazzoccoli G*. Int J Mol Sci. 2019  PMID: 31533246

A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events. El-Athman R, Knezevic D, Fuhr L, Relógio A*. Int J Mol Sci. 2019 PMID: 31443305

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line. Genov N, Basti A, Abreu M, Astaburuaga R, Relógio A*. Sci Rep. 2019  PMID: 31363108

The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes. Fuhr L, Abreu M, Carbone A, El-Athman R, Bianchi F, Laukkanen MO, Mazzoccoli G, Relógio A*. Cancers. 2019 PMID: 31311174

The importance of determining circadian parameters in pharmacological studies. Gaspar LS, Álvaro AR, Carmo-Silva S, Mendes AF, Relógio A, Cavadas C. Br J Pharmacol. 2019 PMID: 31099023

Temporal Splicing Switches in Elements of the TNF-Pathway Identified by Computational Analysis of Transcriptome Data for Human Cell Lines. Genov N, Basti A, Abreu M, Relógio A*. Int J Mol Sci. 2019 PMID: 30857150

— 2018 —

Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes. Castellana S, Mazza T, Capocefalo D, Genov N, Biagini T, Fusilli C, Scholkmann F, Relógio A, Hogenesch JB, Mazzoccoli G. Front Physiol. 2018 PMID: 30190679

The reciprocal interplay between TNFα and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells. Abreu M, Basti A, Genov N, Mazzoccoli G, Relógio A*. Sci Rep. 2018
PMID: 30065253

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer. Fuhr L, El-Athman R, Scrima R, Cela O, Carbone A, Knoop H, Li Y, Hoffmann K, Laukkanen MO, Corcione F, Steuer R, Meyer TF, Mazzoccoli G, Capitanio N, Relógio A*. EBioMedicine. 2018 PMID: 30005951

A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer. El-Athman R, Fuhr L, Relógio A*. EBioMedicine. 2018 PMID: 29936137

Escaping Circadian Regulation: An Emerging Hallmark of Cancer?
El-Athman R
, Relógio A*. Cell Syst. 2018
 PMID: 29596780

— 2017 —

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity. El-Athman R#, Genov NN#, Mazuch J#, Zhang K, Yu Y, Fuhr L, Abreu M, Li Y, Wallach T, Kramer A, Schmitt CA, Relógio A*. PLoS Biol. 2017   PMID: 29216180 

— 2016 —

Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N. Biochim Biophys Acta – Bioenergetics. 2016  PMID: 27060253

Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos. Cela O, Scrima R, Pazienza V, Merla G, Benegiamo G, Augello B, Fugetto S, Menga M, Rubino R, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N. Biochim Biophys Acta – Molecular Cell Research. 2016  PMID: 26732296

— 2015 —

Circadian systems biology: When time matters. Fuhr L, Abreu M, Pett P, Relógio A*. Comput Struct Biotechnol J. 2015  PMID: 26288701

Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock: A Bioinformatics Approach. Lehmann R, Childs L, Thomas P, Abreu M, Fuhr L, Herzel H, Leser U, Relógio A*. PLoS One. 2015 PMID: 25945798

— 2014 —

Ras-mediated deregulation of the circadian clock in cancer. Relógio A*, Thomas P, Medina-Pérez P, Reischl S, Bervoets S, Gloc E, Riemer P, Mang-Fatehi S, Maier B, Schäfer R, Leser U, Herzel H, Kramer A, Sers C*. PLoS Genet. 2014  PMID: 24875049


Tuning the mammalian circadian clock: robust synergy of two loops. Relógio A*, Westermark PO, Wallach T, Schellenberg K, Kramer A, Herzel H. PLoS Comput Biol. 2011  PMID: 22194677

Anopheles gambiae PGRPLC-mediated defense against bacteria modulates infections with malaria parasites. Meister S, Agianian B, Turlure F, Relógio A, Morlais I, Kafatos FC, Christophides GK. PLoS Pathog. 2009  PMID: 19662170

Regulation of clock-controlled genes in mammals. Bozek K#, Relógio A#, Kielbasa SM, Heine M, Dame C, Kramer A, Herzel H. PLoS One. 2009  PMID: 19287494

Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells. Relógio A, Ben-Dov C, Baum M, Ruggiu M, Gemund C, Benes V, Darnell RB, Valcárcel J. J Biol Chem.  2005  PMID: 15546866

Optimization of oligonucleotide-based DNA microarrays. Relógio A, Schwager C, Richter A, Ansorge W, Valcárcel J. Nucleic Acids Res. 2002  PMID: 12034852